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Paxil should be taken once a day, either in the morning or evening, with or without food. Paroxetine is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments. If you begin to feel better, it is important to take Paxil with breakfast. Depression can be triggered or worsened by life's difficulties. It convenient to take Paxil and talk to your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight. It convenient to take Paxil for as long as your doctor advises.