Do not stop taking Diflucan without talking to your doctor. Read all of the Diflucan prescription yeast infection treatment medication before placing your order from the online pharmacy. Do not take Diflucan without first talking to your doctor. Diflucan comes as a tablet and liquid to take by mouth usually taken once a day. Fluconazole is used to treat vaginal yeast infections. Fluconazole is commonly used for prophylaxis in transplant patients. If it is taken at the same time each day.